Bioperine is the trademarked name for a powerful black pepper extract named piperine. This potent natural compound is manufactured by Sabinsa and now commonly found in many supplements such as curcumin, coq10, and resveratrol. Bioperine has been shown to increase the overall bioavailability of these compounds by as much as 20 fold.


Bioperine is a standardized form of the piperine extractive found in the fruit of several species of pepper plants. It’s produced by Sabinsa and is available as a dietary supplement. Bioperine is a thermogenic compound that can help increase the bioavailability of other compounds, such as Tumeric. This novel compound offers some exciting new combinations in the world of nutraceuticals and has the potential to re-frame much of our understanding of herbal formulations.

Benefits of Bioperine

When one purchases a product with Bioperine in it they can be assured it will be almost identical in purity and efficacy from one brand to the next. That helps overcome the huge hurdle of brand variability in the supplement markets around the world. Piperine has been shown to provide many health benefits such as treating diarrhea, acting as a chemopreventative, modulating the immune system, and even helping reduce seizures in patients with epilepsy (R). One of Bioperine’s most notable benefit is its ability to increase the bioavailability of many other compounds. When taken in conjunction with compounds such as turmeric, resveratrol, and CoQ10, piperine can increase bioavailability by as much as 2000% in some cases. Below you’ll find a brief discussion of specific examples of piperine/Bioperine’s synergistic action.

Bioperine + Tumeric

There are plenty of applications where a co-administration of piperine may well lead to better overall absorption. One of the initial studies to highlight bioperine’s potential as a synergistic agent compared the absorption of turmeric within rats and human volunteers. One of the study’s primary goals was to compare the different absorption rates of turmeric between human and mice, not necessarily to highlight the overall benefit of Bioperine alongside turmeric. Nonetheless, researchers noted that when Bioperine was taken with turmeric, human volunteers were observed to have 2000% higher levels of serum curcuminoids (R).

Bioperine + Resveratrol

Resveratrol was revered as the de-facto anti-aging supplement for a number of years. It’s also a powerful cardioprotective agent with known anti-inflammatory and antioxidant properties (R). The trouble is that resveratrol is rapidly metabolized after consumption and its effects are often marginalized in human observation. Researchers have demonstrated that, much like turmeric, resveratrol’s bioavailability is increased by over 1500% when taken alongside Bioperine (R).

Bioperine + CoQ10

Coenzyme Q10 is a powerful anti-inflammatory and anti-radical compound that is produced naturally by the human body. Insufficient CoQ10 levels have been linked to increased risk for many major diseases including heart attack, stroke, and cancer. In some limited studies, researchers have noted increases of up to 30% in the bioavailability of CoQ10 when taken in conjunction with piperine extractives (R).

Standardized Formulation

Dietary ingredients such as piperine are regulated by the FDA in ways very different than how pharmaceutical compounds are regulated. The FDA’s GMP guidelines for dietary supplements help improve consumer safety by helping assure products are produced under a certain level of quality control. Still, these guidelines are argued as being preventative measures in most cases. In other words, the FDA doesn’t step in until there’s already a problem.

Bioperine represents a class of compounds that are produced through standardized and patented production methods, often by a single source. In the case of Bioperine, all products containing it as an ingredient have been sourced (at least partially) from Sabinsa. This approach of centralized sourcing helps consumers rest assured that the piperine quality in one product with Bioperine will be virtually identical to another.


BioPerine is a standardized form of the black pepper extract piperine. It offers a well-controlled means of sourcing a very potent compound for supplement distributors. It’s remarkable ability to enhance the bioavailability of beneficial compounds like resveratrol, curcumin, and coenzyme Q10 have made it a popular addition synergistic ingredient in many supplements. Even with standardized ingredients such as Bioperine, it’s important to adhere to strict quality standards when purchasing supplements. This will ensure potency, efficacy, and purity and also help you from wasting your money. Check out our list of the best supplement brands to better understand which brands offer the highest level of consumer and doctor trust.

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