Calcium D-Glucarate is the calcium salt produced from the naturally occurring compound glucaric acid. This compound is commonly found in fruits such as oranges, grapefruits, and apples. It is known to help inhibit some toxic substances’ effect on the liver, aid in the management of chemotherapy symptoms, and has shown potential in helping to prevent major diseases such as colon, ovarian, breast, and other hormone-dependent cancers.

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Powerful Detoxification Support

Calcium D-Glucarate is considered to be a more bio-available oral form of glucaric acid and acts as a powerful β-glucuronidase inhibitor. This compound is currently being researched for several medical and dietary applications and is available for purchase without prescription in the United States as a dietary supplement (R).

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Glucaric Acid Analogue

Calcium D-Glucarate is a very close associate of glucaric acid and is widely understood to have powerful antioxidant, detoxification, as well as preventative powers towards our health. The exact methods and motus operandi of Calcium D-Glucarate have yet to be fully-understood but researchers have made great strides in recent years. A better understanding of several compounds related to Calcium D-Glucarate, and it’s action within our bodies, can help better understand the potential health benefits of this compound.

Glucaric Acid

Also known as Saccarhic Acid, Glucaric Acid is formed naturally by the oxidation of glucose with nitric acid (R). This naturally-occurring compound is found in many fruits, as well as being naturally-produced in humans and mammals. Research has shown that this potentially cancer-preventative compound is commonly found in grapes, broccoli, apples, lettuce, and several other fruits mostly of the citrus variety. Apples, for example, contain 3.5 grams of glucaric acid per measured kilogram (R). It’s always enlightening to understand the basis for such common phrases as “an apple a day—keeps the doctor away!”


Often written as β-Glucuronidase, this compound is a nasty little enzyme that is thought to be produced by harmful bacteria residing in our gastrointestinal (GI) tract. There are trillions of microbiota that take up residence in our gut, which include many of the beneficial ones included in most probiotic supplements, such as Lactobacillus Rhamnosus. These micro-residents help to break down foods, detoxify our bodies, as well a whole host of other beneficial actions that help us to live long healthy lives.

Gut-Brain Connection

The dynamics of how these small creatures affect our health isn’t fully understood, but research suggests that much of what we deal with on a physical and emotional level, may be able to have its roots traced back to our gut. For example, one study found that colon cancer patients had 12 TIMES as much β-Glucuronidase in their fecal matter than other cancer-free participants (R).

Liver Impact

In addition to being a product of an unhealthy gut flora balance, β-Glucuronidase is also capable of disruption of Phase II liver detoxification. When in the liver, this compound is capable of breaking the bonds between Glucuronic acid and harmful compounds. Glucuronic acid is utilized by Phase 2 pathways of the liver in a process called Glucuronidation.

 β-Glucuronidase is a compound that can wreak some serious havoc when found in amounts beyond normal levels

It’s during this process that glucuronic acid attaches to harmful substances and helps to carry them out of the liver and into the gut for removal. By disrupting this process, β-Glucuronidase makes effective liver detoxification more difficult and, in chronic cases, can lead to jaundice. Simply put; β-Glucuronidase is a compound that can wreak some serious havoc when found in amounts beyond normal levels.

The Helpful Calcium D-Glucarate

In addition to being a powerful antioxidant, Calcium D-Glucarate is also an effective β-Glucuronidase inhibitor (R). This inhibitory action not only allows the liver to cleanse the body of harmful substances more effectively but has also shown the ability to prevent cancer through the detoxification of carcinogens and their precursors (R). No one is calling this a “Cure” for cancer; just a potential preventative aid and a detoxifying aid during traditional Cancer treatments such as chemotherapy.

Potential Cancer Treatment

Calcium D-Glucarate is the salt form of glucaric acid—which has been shown to provide tremendous ability in the treatment of cancer as well as chemotherapy symptoms. In addition to the blocking of β-Glucuronidase as mentioned above, Calcium D-Glucarate has been shown to create hormonal changes in target organs, such as those affected by tumor growth. In some studies, Calcium D-Glucarate supplementation was shown to reduce tumor growth by up to 70%! (R)

Toxin-Blocking Action

Calcium D-Glucarate’s detoxifying action can also be helpful for those who eat diets high in fats and proteins. The digestive processes involved with eating protein can produce several toxic by-products such as ammonia, which can cause a decrease in liver function. The ability to help block these toxic chemicals can allow for greater overall liver functionality.

Non-Traditional Diet Support

In addition, diets like the ketogenic diet, where gluconeogenesis-like metabolic processes are utilized, the liver is often put under a much larger workload than typical high-carb diets. This extra stress can sometimes cause unwanted side effects such as slow recovery times, chronic sickness, as well as many other symptoms (R).

Calcium D-Glucarate Supplements

Calcium D-Glucarate is a readily-available compound on the consumer market but doesn’t always find its way into local supplement stores. It’s a bit tricky to produce and often winds up being a bit too expensive to order on a whim (at least for smaller local shops.) Online, however, you’ll find several options for Calcium D-Glucarate that contain high-quality ingredients are manufactured by trustworthy supplement brands. The product that offers the best overall balance of quality and price is the Calcium D-Glucarate by Douglas Laboratories. You’ll find this product has no unnecessary ingredients, offers a potent form of Calcium D-Glucarate, and is manufactured by a brand trusted by health professionals.

Final Thoughts

Calcium D-Glucarate might not be a household name but it certainly has the potential to offer many benefits. Overall, it seems most accurate to classify this compound as a detox supplement but, at least at its core, it’s still a calcium supplement. It has great promise in the field of cancer therapies and mitigating the side effects of traditional therapies such as radiation and chemotherapy. Overall, this compound is one of the more unique minerals on the consumer market and should be on the radar of anyone who eats a high protein diet or requires supplemental detoxifying support.

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