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Calcium D-Glucarate is the calcium salt produced from the naturally occurring compound glucaric acid which is commonly found in fruits such as oranges, grapefruits, and apples. It is known to help inhibit some toxic substances’ effect on the liver, aid in management of chemotherapy symptoms, as well as showing potential to help prevent major diseases such as colon, ovarian, breast, and other hormone-dependent cancers such as prostate cancer.

Powerful Detoxification Support

Calcium D-Glucarate is considered to be a more bio-available oral form of the glucaric acid compound, acting as a powerful β-glucuronidase inhibitor. This compound is currently being researched for several medical and dietary applications, and is available for purchase without prescription in the United States as a dietary supplement 1. Calcium D-Glucarate is a very close associate of glucaric acid, and is widely-understood to have powerful antioxidant, detoxification, as well as preventative powers towards our health. While the exact methods and motus operandi of Calcium D-Glucarate have yet to be fully-understood, researchers have been furthering our understanding constantly. A better understanding of several compounds related to Calcium D-Glucarate and it’s action within our bodies, you will be able to decide if it may benefit you.

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Glucaric Acid

Also known as Saccarhic Acid, Glucaric Acid is formed naturally by the oxidation of glucose with nitric acid 2. This naturally-occurring compound is found in many fruits, as well as being naturally-produced in humans and mammals. Research has shown that this potentially cancer-preventative compound is commonly found in grapes, broccoli, apples, lettuce, and several other fruits mostly of the citrus variety. Apples for example, contain 3.5 grams of glucaric acid per measured kilogram 3. It’s always enlightening to understand the basis for such common phrases as “an apple a day—keeps the doctor away!”


Often written as β-Glucuronidase, this compound is a nasty little enzyme that is thought to be produced by harmful bacteria residing in our gastrointestinal (GI) tract. There are trillions of microbiota that take up residence in our gut, which include many of the beneficial ones included in most probiotic supplements, such as Lactobacillus Rhamnosus. These micro-residents help to break down foods, detoxify our bodies, as well a whole host of other beneficial actions that help us to live long healthy lives.

“Attaches to harmful substances and helps to carry them out of the liver and into the gut for removal”

The dynamics of how these small creatures affect our health isn’t fully understood, but research suggests that much of what we deal with on a physical and emotion level, may be able to have it’s roots traced back to our gut. For example, one study found that colon cancer patients had 12 TIMES as much β-Glucuronidase in their fecal matter than other cancer-free participants 4.

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In addition to being a product of an unhealthy gut flora balance, β-Glucuronidase is also capable of disruption of Phase II liver detoxification. When in the liver, this compound is capable of breaking the bonds between Glucuronic acid and harmful compounds. Glucuronic acid is utilized by Phase 2 pathways of the liver in a process called Glucuronidation 5. It’s during this process that glucuronic acid attaches to harmful substances and helps to carry them out of the liver and into the gut for removal. By disrupting this process, β-Glucuronidase makes effective liver detoxification more difficult and, in chronic cases, can lead to jaundice.

Calcium D-Glucarate

Calcium D-Glucarate is known to be a powerful antioxidant 6 as well as an effective β-Glucuronidase inhibitor. This inhibitory action not only allows the liver to cleanse the body of harmful substances more effectively, but has also shown the ability to prevent cancer through the detoxification of carcinogens and their precursors 7. While much more human testing needs to be done to substantiate these findings further, studies with rats demonstrated a 60% reduction in cancer rates!

Our bodies evolved learning how to produce enough Glucuronic acid to help detoxify our bodies from the harmful compounds that we were exposed to on a regular basis. As with many other health and dietary-related issues, the overwhelming presence of modern synthetic chemicals has caused us to be bombarded by compounds our bodies haven’t had very long  to get used to. We spent the majority of our evolutionary development being exposed to the worst compounds that Mother Nature could throw our way, all the while tooling up to handle them in the future. Now, we are faced with foreign invaders which our body has little experience with, and can be easily overwhelmed. It’s kind of like training for a lightweight boxing match, only to step into the ring with a heavy-weight.

Cancer Treatment

Calcium D-Glucarate is the salt form of glucaric acid—which has been shown to provide tremendous ability in the treatment of cancer as well as chemotherapy symptoms (7). In addition to the blocking of β-Glucuronidase as mentioned above, Calcium D-Glucarate has been shown to create hormonal changes in target organs, such as those affected by tumor growth. This hormonal shift, combined with affect on the way the body produces natural steroidal compounds, allows Calcium D-Glucarate to exhibit “anticancer action.” This means of treatment has been also been shown to greatly reduce the presence of toxins in the liver by helping to flush them into the urinary tract, later eliminating them.

“In some studies, Calcium D-Glucarate supplementation was shown to reduce tumor growth by up to 70%”

This type of detoxifying action can also be helpful for those who eat diets high in fats and proteins. The digestive processes involved with eating protein can produce several toxic by-products such as ammonia, which can cause a decrease in liver function. The ability to help block these toxic chemicals can allow for greater overall liver functionality. In addition, diets like the ketogenic diet, where gluconeogenesis-like metabolic processes are utilized, the liver is often put under a much larger workload than typical high-carb diets. This extra stress can sometimes cause unwanted side effects such as slow recovery times, chronic sickness, as well as many other symptoms 8. In some studies, Calcium D-Glucarate supplementation was shown to reduce tumor growth by up to 70%! 9

Hormonal Balance

Calcium D-Glucarate has also been shown to help balance hormone levels, helping you to cultivate a more consistent state of being. It does this through its ability to decrease to overall amounts of β-Glucuronidase throughout the bloodstream. This has an overall impact on estradiol levels, which is a precursory component to estrogen. In addition, Calcium D-Glucarate has demonstrated the ability to greatly impact ketosteroidal levels, which have a hormonal impact as well.

Calcium D-Glucarate Supplements

Calcium D-Glucarate has proven itself as having great potential in helping to achieve optimal health. By addressing cancerous tumors, aiding liver detoxification, and balancing hormonal levels, this compound is understood as an essential element within our bodies. Currently, this compound is available for purchase without a prescription from a licensed medical professional, and can be done safely online. I would recommend the Calcium D-Glucarate by Douglas Laboratories  or Pure Encapsulations which are both very pure forms of this supplement—both from very well-respected manufacturers. To learn more about choosing a quality supplement read our article The Best Supplement Brands for an in-depth look at some of the best brands on the market—and how they’ve each earned that title.

Calcium D-Glucarate
Powerful Liver Aid
Calcium D-Glucarate is a powerful form of calcium that helps the liver to eliminate toxic loads much more efficiently. Research has shown it to be a powerful antioxidant that may help to treat many diseases—including certain types of cancer.
Detox Support
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