Human Growth Hormone (HGH) helps regulate a myriad of essential processes in our bodies. It plays a vital role in cellular regeneration, cell reproduction, and growth in general. HGH also works on a cellular level to reduce oxidative stress, aids in digestion, and even helps support a healthy sex drive. Learning some of the science behind HGH supplements can help better understand which compounds will help give you the boost you need and which ones are just marketing hype.


Growth Hormone is produced by the somatotropic cells within the anterior region of the human pituitary gland (R). This region of the brain is responsible for the production of many another important chemicals such as leutinizing hormoneAdrenocorticotropic hormone (ACTH), Thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH.) Each of these plays a vital role in the body but are separate (at least mostly) from matters of growth hormone.

Brain Damage

Nonetheless, research has evidenced that HGH supplementation among those having experienced traumatic head injuries can reverse symptoms of HGH deficiency (R). There isn’t solid research to describe the progression of compromised HGH production (or overall pituitary function for that matter) among humans. Diagnosing an HGH deficiency is a particularly difficult process that involves multiple sampling assays taken throughout the day. This direct method of testing is expensive, burdensome, and rarely the first course of action. Initial testing to assess growth hormone production is done by the measure of Insulin-like Growth Factor 1 (IGF-1).

It’s important to recognize the difficulty of testing to better understand the likely gaps in research. Many head injuries that likely result in compromise pituitary health also likely go undiagnosed as such. One study conducted on rats found that traumatic brain injuries can have a profound impact on pituitary function and HGH production throughout the remaining lifespan of the animal (R). This is all important to keep in mind to recognize that there isn’t solid science to describe what the long-term effects of reduced HGH production might involve.

HGH Supplements

No supplement will ever compare to the efficacy of synthetic HGH injections. That should be made abundantly clear. There are several natural compounds that have demonstrated a remarkable ability to increase HGH levels ( at least during acute periods ). Before you start shopping, also keep in mind that marketers have a field day with HGH supplements. As with any supplements, it’s important to buy from trusted brands to ensure product quality. The funny thing; most of these brands won’t try to sell you an HGH Booster either—because they can be trusted to represent their products fairly as well. Below you’ll find a list of the best hgh supplements available for those with reasonable expectations.


L-Arginine is an amino acid associated with building protein structures within your body. This compound is found naturally in foods like meat, eggs, and dairy. It’s considered a non-essential amino acid, helps fight inflammation, repairs blood vessels, help to lower blood pressure, increases overall immune function, and even prevent the common cold (R). As if L-Arginine needed any more feathers in its cap; it also helps increase HGH levels (R).


L-Ornithine is an intermediary compound within the human body’s Urea Cycle, located primarily in the liver. This cycle is integral to the reduction of ammonia in the bloodstream. L-Ornithine may also show some ability to address conditions related to kidney and liver dysfunction, such as hepatic encephalopathy.  L-Ornithine also promotes the stimulation of IGF-1 levels when taken before workouts or physical exertion (R). L-Ornithine’s reduction of ammonia concentrations is also tied to the reduction of fatigue symptoms. Not only will L-Ornithine help increase HGH levels directly but allowing for longer, more intense, workouts will help boost HGH indirectly.

Alpha GPC

Alpha GPC (Alpha-glycerophosphocholine) is a choline-bound compound that has been shown to benefit health in many ways. Alpha GPC is a novel compound because it has been shown to readily cross the blood-brain barrier.  The interest in Alpha GPC for growth hormone stimulation revolves heavily around a study in which acute spikes of growth hormone were observed when large doses were taken before workouts (R).


L-Dopa is another amino acid compound that is found naturally in foods like velvet beans, and is a direct precursor to the ‘feel good’ neurotransmitter Dopamine. In clinical tests, L-Dopa has shown the ability to increase levels of circulating growth hormone (R). L-Dopa is popular among many men as a penis-enlargement supplement, having demonstrated the ability to increase penile girth naturally. The research indicating this ability of L-Dopa also saw a correlation between the increased penile size and amounts of testosterone available (R).

Gamma-Aminobutyric Acid (GABA)

GABA is involved in one of the most integral neural pathways within your brain, and is responsible for a myriad of vital operations. GABA is most-associated with the reduction of stress, and acts as a ‘downer’ neurotransmitter which balances out the actions of glutamate pathways. In addition to exhibiting anti-anxiety effects, GABA has also demonstrated the ability to increase growth hormone levels during periods of rest and exercise (R)

Realistic Expectations

HGH supplements aren’t likely to offer any profound effects. They’re often marketed as the next-best-thing to steroids and actual HGH injects but that’s just not the case. Research describing these supplements’ ability to increase HGH levels during, before, and proceeding exercise are pretty robust. There haven’t been any huge studies on the subject but there are many done across many areas of focus that observe similar effects. In short, these supplements are very likely to cause short-lived acute spikes in growth hormone levels. The catch is that short bursts simply don’t compare to the natural production of HGH by the human pituitary gland. In other words; you’ll get an increase in HGH but it just won’t offer the benefits many people associate with such spikes.

Final Thoughts

Human growth hormone is involved in many processes in our bodies that help reduce inflammation, remove toxins, and build new protein structures such as muscle. Brain damage or certain bacterial infections may leave the anterior pituitary gland in a compromised state, thus creating a scenario of life-long HGH insufficiency. These conditions are difficult to diagnose, impossible to get covered by insurance, and still not categorically described by scientific data. The natural HGH supplements listed here have all demonstrated the ability to spike HGH levels in clinical study. It’s probably a better idea to try them individually than buy an “HGH Booster” supplement that’s packed with everything under the sun.

How’d We Do?

Articles such as this one are near and dear to our hearts. HGH insufficiency can be a difficult condition to live with. We hoped to provide some non-prescription options as well as provide a realistic impression of what to expect of them. Let us know how we did by rating this article.

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