Lithium Orotate is specific form of elemental lithium that has powerful potential in addressing serveral major neurological conditions and issues such as migraines, Alzheimer’s, Shock, and even Diabetes. This curious compound is similar to the lithium drug most people are familiar with, except that it is found in a monohydrate form bound to a Orotic Acid molecule. This particular form of lithium is thought to be more bio-available, allowing it to provide a more profound effect at much lower doses than other forms such as Lithium CarbonateThis means that with lithium orotate you get all of the neurological benefit lithium has to offer, without risk of the dangerous lithium side effects.

Lithium Orotate has been studied as an effective treatment for Alcoholism and related conditions (1) and is thought by many to be effective in treating a wide variety of other conditions (2) like depression, bi-polar disorder (3), insomnia, hormonal imbalance, and even digestive issues. Currently Lithium Orotate is not approved by the FDA for the treatment of any disease or disorder, and is sold without prescription as a dietary supplement. However, many people have been known to utilize lithium for anxiety. Most people are familiar with Lithium Carbonate, the traditionally-prescribed medication for Bi-Polar disorder, and assume any lithium Product is prescription-only—that’s not the case at all. Lithium Orotate supplements, Vital Nutrients’ Lithium Orotate 5MG is an over-the-counter type compound that can be legally purchased by anyone—assuming you can find it.

NOTE: If you’re just interested in learning where to buy Lithium Orotate, skip to the Buying Lithium Orotate Online Section at the bottom of this article

Lithium is often associated with its historical use as a prescription treatment for mental disorders such as schizophrenia and bi-polar disorder. Typical doses administered for this purpose are as high as 1200mg/day for an average adult (4). These types of massive dosages have led to the assumption that lithium is capable of doing a great deal of harm to your body. A large factor for risk of Lithium toxicity, is the amount one must take to allow a beneficial amount into the bloodstream. Lithium Orotate on the other hand, is able to enter the bloodstream much more easily, so much lower doses are able to achieve the same effects.

“Lithium has demonstrated remarkable benefit in the treatments of Alzheimer’s, Type II Diabetes, Shock, Inflammation, Schizophrenia, and many metabolic disorders within the body”

Lithium toxicity is largely understood through the data gathered with those patients taking the compound in its Carbonate form, which is thought to be less bio-available than Lithium Orotate (7.) This data has been split into three sub-categories of toxicity; Acute, Chronic, and Acute-Chronic Toxicity (5). The symptoms associated with Lithium Carbonate toxicity are diarrhea, dizziness, nausea, vomiting and generalized weakness, tremors, ataxia, muscle twitches, seizures, or slurred speech. These are the symptoms most commonly-associated with acute toxicity. Symptoms of chronic toxicity are similar except that psychosis tends to develop as well, exhibited by strange behaviors. Lithium Orotate is able to avoid these horrible side-effects, while still providing the powerful neuro-protective effects of Lithium.

Benefits of Lithium Orotate

The benefits of Lithium have been clinically studied to some extent and have substantiated benefits in addressing several mental/cognitive disorders. In addition, Lithium has been shown to exhibit neuro-protective abilities as well as having a beneficial impact on the central nervous system (8.) Lithium has been exhaustively documented as being an effective Glycogen Synthase Kinase-3 (GSK-3) inhibitor, which is the mechanism by which it is thought to help treat bipolar disorder. Acting as a neuroprotector, Lithium has demonstrated a wide spectrum of ability to help curb disease and disorders rooted in neuro-degeneration. Through this mechanism, Lithium has been shown to show benefits in the treatments of Alzheimer’s, Type 2 Diabetes, Shock, Inflammation, Schizophrenia, and many metabolic disorders within the body (9). As modern research learning more clearly, inflammation is associated with many age-related disorders as well as major diseases such as cancer. It would would be reasonable to say that through Lithium’s ability to address chronic inflammation, that it has the potential to address those major diseases thought to be largely rooted in inflammation such as cancer (10.)

Lithium Orotate & FDA Regulations

Lithium Carbonate, being the most well-known form of prescription lithium,  is usually recommended as a 120mg Dose, which contains only 4mg of actual elemental Lithium, up to 3 times a day. These are the larger doses of Lithium Carbonate associated with conditions such as bipolar disorder and other more severe mental disabilities, which are known to cause severe side effects such as kidney failure and hallucinations.

Lithium Orotate however, is capable of providing a slightly higher amount of available elemental lithium at much lower doses—as little as only 20mg per day. Lithium Orotate is currently not FDA approved to treat any condition or disease, and is considered to be a dietary supplement. The United States is in a peculiar state when it comes to making claims towards the benefits of a particular dietary product. For example, a Lithium Orotate product on Amazon is allowed to have customer reviews about the element’s benefits, potential treatments, as well as other subjective impressions. Take Advanced Research’s Lithium Orotate for example; this product has many reviews—several of which detail the product’s ability to drastic change lives for the better. A few examples of the testimonials given are as follows:

  • I have been using lithium orotate for a short time and have already stabilized my depression and mood swings more than any other time
  • Then I tried this product. Almost immediately I just felt “good”!! Happier, ‘life’ just didn’t seem so ‘heavy’, things were manageable
  • Did I mention there are no side effects? This is a bona fide godsend. Do the homework, then buy this product.
  • I did extensive research and found this product had the best overall capability to treat my Bi-Polar

These reviews reinforce the idea that Lithium Orotate is able to treat emotional disorders, as well as other health concerns effectively, and with little chance for side effects. Now take another example—a small company called Bio-Recovery—which sells several dietary supplements marketed as products to aid the body in detoxification. In 2014 this company had an on-site inspection by the FDA, as well as an audit of their website and it’s marketing practices. Below is an excerpt from the Warning Letter sent to Bio-Recovery by the FDA (6) post-audit:

Specific examples of some of the website claims that provide evidence that your products are intended for use as drugs are below.  Your website also contains evidence of intended use in the form of personal testimonials recommending or describing the use of products for the cure, mitigation, treatment, or prevention of disease.

As you can see, Bio-Recovery was handed a warning by the FDA for having such statements publicly-seen on their website, while Amazon is allowed to keep chugging along.The legal framework that separates the ability of a company to associate beneficial claims with a dietary supplement is not only complex, but to the layman like you and I— it seems to even bit contradictory of itself. The take away from the grey area in which dietary supplements fall in the United States is this; you are able to freely purchase powerful dietary supplements, but you can’t sue someone if you have an adverse effect. This means that Lithium Orotate supplements are viewed, legally speaking, the same as common magnesium supplements, and other more common types of dietary supplements. This circumstance is highly beneficial—if you know which supplement brands contain pure ingredients free of harmful fillers or bizarre ‘inactive’ ingredients—in that there is a highly competitive market free of patents where quality products are available at a reasonable price.

Lithium Orotate vs. Lithium Carbonate

Lithium Orotate is an ionized form of lithium, technically a salt similar to potassium, and has the ability to cross the blood-brain barrier much more easily than Lithium carbonate. The result of this more bio-available form is that much lower dosages can be used to achieve the same neurological benefits as seen with other forms such as lithium carbonate.

“A 5MG dose [of Lithium Orotate] is able to provide the benefits of a 180MG dose of Lithium Carbonate”

The dosage amount of Lithium Carbonate, which is the form commonly prescribed by doctors for treatment of bipolar disorder, can be as high as 180mg per dose. Lithium orotate, by contrast, may have a dosage of 150mg, but only roughly 5mg of that dose is elemental Lithium. The molecular state of Lithium orotate makes it so that that 5mg dosage is able to provide the benefits of the 180mg lithium carbonate dosage. The result is Lithium Orotate providing all the benefits of lithium carbonate, but with none of the toxic side-effects resulting from large doses. In clinical trials, this distinction was expressed by the observance of a reduction of manic and depressive symptoms in patients (7.)

Buying Lithium Orotate Online

The FDA does not currently approve Lithium Orortate for the treatment of bipolar disorder, which allows it to be purchased without prescription. For example, there are a large variety of Lithium Orotate products to choose from online, all of which can be purchased without a prescription. Some brands such as Pure Encapsulations offer synergistic blends of Lithium Orotate, which incorporate other supplements thought to promote healthy neural function such as N-acetyl-cysteine (NAC.) If you’re planning on beginning a Lithium Orotate supplement, you should do so only after consulting a licensed healthcare professional, whom will help you better understand dosage as well as monitor your long-term usage.

Vital Nutrients Lithium Orotate Best Supplement Brands

Lithium Orotate by Vital Nutrients Click to View Online

Assuming you’ve already consulted a professional, and you are simply looking for a trusted  place to purchase your supplements; this section is for you. To get a better understanding of the best supplement brands available on the market, check out our article The Best Supplement Brandswhich details the best brands on the market today, as well as personal experiences and reviews of each.

A great Lithium product, that is available on the Pureformulas website, is the Lithium Orotate by Vital Nutrients

The second most important facet of shopping for supplements online, is finding a trustworthy retailer. I’ve tried many companies over the years such as Swanson Health Products, The Vitamin Shoppe, VitaCost, and, and even Amazon. While these companies represent a collective in which you can usually find whatever product you’re looking for, none offer the specialization that one would expect to find from a retailer of pharmaceutical grade supplements. carries well over 40,000 products and is one of the few retailers that are large enough to deliver excellent service, while still being committed to helping you find the best supplements. Another wonderful facet of Pureformulas is the list of Doctor Trusted Brands which lists all the supplements manufacturers that are trusted by healthcare professionals worldwide to offer the most potent forms of treatment available.

A great Lithium product that is available on the Pureformulas’ website is the Lithium Orotate by Vital Nutrients. This product is commonly recommended by integrative doctors and other ‘alternative’ medical practitioners looking to provide their patients with a robust treatment while avoiding toxic side effects. This product is known to be slightly more expensive than other brands, but is an extremely high quality supplement. If you are looking for something slightly cheaper, I’d suggest the Lithium Orotate by Ortho Molecular, priced much more reasonably, but for a slight . I’ve had a very positive experience with this company’s products, particularly their Vitamin K-2.

Vital Nutrients Lithium Orotate Best Supplement Brands
Vital Nutrients Lithium Orotate
Doctor-Trusted Brand, Recommended By Healthcare Professionals
Quality Ingredients with NO Fillers or Harmful Ingredients
Shown in Studies to Provide POWERFUL Neuroprotective Action
Doesn't Have Bad Side Effects Like Regular Lithium
Available Without Prescription
Slightly More Expensive Than Other Brands
Safe & Effective Lithium Supplement
Lithium Orotate has been shown in many studies to exhibit powerful neuroprotective properties, and to be effective in many major diseases such as Alzheimer's, Shock, Bi-Polar Disorder, and even Diabetes. Lithium Orotate from Vital Nutrients is an excellent version of this supplement from a Doctor Trusted Brand, and available for purchase online from retailers such as Pureformulas.



Lithium is a powerful compound in its ability to address several major mental disorders, as well as a plethora of other major medical conditions. It’s neuroprotective properties have been outweighed in the past by the accumulated toxicity of those large dosages. Lithium Orotate is form of lithium in which the elemental molecules are able to cross the blood-brain barrier much more easily, thus allowing a much smaller effective dose to be administered. This lower dosage provides all the benefits of lithium carbonate, but doesn’t cause the side effects. Currently the FDA does not approve of Lithium Orotate for the treatment of any disease, but there is a fairly-large amount of clinical data, as well as public sentiment, that Lithium Orotate is able to exhibit some remarkable health benefits.

For those curious in trying Lithium Orotate, it can be legally purchased online, without prescription. Retailers such as offer a wide variety of harder to find supplements such as these, and also provide a large catalog of Doctor Trusted Brands which are know to contain only the purest ingredients.

NOTE: The information in this article is provided solely for educational purposes and is not intended to serve as qualified medical advice. As with any dietary supplement or medication, you should seek the advice of a licensed healthcare professional to help you decide if a product is right for you.


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