The use of dietary supplements has increased considerably in recent times—attributed largely to a growing awareness of potential side effects from synthetic, prescription medications. Proper supplementation can help fill nutritional gaps in one’s diet, as well as address very specific imbalances within the body. With this increase in usage has come the expected increase in supplement brands to choose from.

While many manufacturers may sell a supplement labeled with the same ingredients, there are certain trusted brands offering pharmaceutical grade supplements that are trusted and used by healthcare professionals. These high quality brands offer pure ingredients free of fillers, additives, contaminants, and are guaranteed to contain the ingredients listed on the labels—and are considered to be pharmaceutical grade supplements.

You typically get what you pay for with supplements; the more expensive brands being the most pure, and the cheaper brands using extra fillers

Supplements are regulated by the FDA as food products, and are subject to much less scrutiny of efficacy before hitting the store shelves. Clinical trials aren’t require as are with prescription medication, which allow many manufacturers to get away with adding fillers and unwanted materials. What this means is, that while you may have much easier access to supplements than prescription medications, you must pay much more attention to the quality of product you are getting.

Luckily, there are quite a few brands available now that are doctor-trusted supplements, and adhere to the guidelines pharmaceuticals manufacturing. You typically get what you pay for with supplements; the more expensive brands being the most pure, and the cheaper brands using extra fillers, questionable inactive ingredients, and overall less pure ingredients.

Dangers of Untrusted Supplements


Supplements Containing Fillers & Other Ingredients

As reported by The New York Times, a Canadian research group conducted a study among many different generic brand supplements, using DNA testing to verify their ingredients. They found that many of these supplements, most common to grocery stores such as Walgreens and Wal-Mart, contained unlisted fillers, contaminants, completely different compounds than listed, and in some cases no active herbal ingredients at all! They found that over 60% of the store brand supplements tested had incorrect labeling, and more than 50% of those tested didn’t contain the advertised ingredient! For example, two of the bottle tested were of St. John’s Wort, which has been shown to have the ability to treat mild symptoms of depression. As it turned out, neither one of the tested bottles contained St. John’s Wort—one contained nothing but rice, and the other a powerful Egyptian-native shrub that is a powerful laxative! This study proved that the use of un-trusted supplements can not only be ineffective but also dangerous.

Over 60% of the store brand supplements tested had incorrect labeling, and more than 50% of those tested didn’t contain the advertised ingredient!

With such a presence of inferior supplement products on the market, it is very important to make sure you are buying a high quality product from a highly-trusted manufacturer. There are many brands available that offer products considered to be pharmaceutical grade supplements. These are supplements that are produced under rigorous laboratory conditions, tested for purity, contaminants, and are free of allergens and questionable ingredients. These supplements are regarded as the top-tier of quality within the vitamin and supplement world, and are often prescribed by Integrative Doctors as well as Holistic and Naturopathic Practitioners. These products are also offered with many synergistic compounds to help increase the bio-availability of the active ingredient. This means is that not only are pharmaceutical grade supplements a purer product, but most times more able to be absorbed properly by your body. You can be sure that you will be getting only those ingredients listed on the labels, and that there will be no surprises.

Why Pharmaceutical Grade Supplements are Important


Quality of Supplement Ingredients Matter

Health is much like a balancing of scales, in that many things are inter-connected and the changing of one may affect another. Dietary and nutritional supplementation is an effective means by which to address certain imbalances such as depression and anxiety, without great risk of complication or negative effect.

The complexity of the human body can often make narrowing down pathology a tricky business. After beginning a new supplement, you may notice that some symptoms improve while new ones appear. Keeping an accurate account of the changes and response in your health is paramount, ensuring that you aren’t being exposed to any unknown substances is also of vital importance. For example, you may have just started a supplement to address what you feel to be excessive hunger. This supplement may have effectively reduced your cravings to eat between meals, but at the same time have caused you to become slightly lethargic. This type of situation is common when determining a best course of dietary supplementation, as you learn how your body responds to different compounds.

All true pharmaceutical-grade supplements are produced in a non-allergen facility free from dairy, eggs, wheat, gluten, nuts, and other ingredients viewed as common allergens

If you are taking supplements that aren’t considered to be pharmaceutical grade, you very well may be ingesting many more ingredients than you know. If you have a negative reaction to this type of supplement, it can be hard to know if the active ingredient is what is causing you an  issue, or if it is one of the “inactive” ingredients. Avoiding this type of peril is critical for those suffering from allergies or food sensitivities. All true pharmaceutical-grade supplements are produced in a non-allergen facility free from dairy, eggs, wheat, gluten, nuts, and other ingredients viewed as common allergens. This means production equipment isn’t shared with food processing machines, nor produced in the same facility with other allergens.  Maybe you’ve seen a label before on something you’ve bought that says something to the effect of “produced in a facility that also produces tree nuts, peanuts, wheat, and dairy.” These are especially common to store brand food items, since manufacturers often use the same equipment to package all their products. You WILL NOT see this label on any supplement that is truly pharmaceutical-grade.

Trusted Supplement Manufacturers

You won’t find many pharmaceutical grade supplements in your local health-food store, and large chains such as The Vitamin Shoppe don’t carry many of them either. Most health care professionals such as Integrative Doctors, Naturopaths, or Holistic Practitioners commonly prescribe these types of supplements to their patients—and often keep their own inventory. This is the best method of gaining access to these types of quality supplements—because it comes with the direction and consult of a trained professional. In some cases you’ll be able to find a few products offered by these brands locally, but usually only a fraction of the manufacturers’ complete line.

If you don’t have this type of local access, there are several online retailers which offer many of the pharmaceutical grade supplements a health practitioner may offer. The brands that fall into pharmaceutical grade range of quality are often carried by retailers that offer very competitive pricing, discounts, as well as very reasonable shipping fees.

Health care professionals such as Integrative Doctors, Naturopaths, or Holistic Practitioners commonly prescribe these types of supplements to their patients

These same high quality brands will also have their version of most vitamins or supplements you are looking for, as well as many other more specific options to choose from. When you get to this level of supplement quality, there are often several different versions of the same supplement; offered with different fortifying agents, different encapsulation methods, and several other variations used to ensure that these high-potency formulas are able to be utilized fully by your body.

These supplements are for those looking to get the best impact possible, while keeping exposure to unwanted contaminants such as pesticide residues and filling agents to a minimum. For the scope of this article, we will be focusing on a single supplement manufacturer to better address all the different variables that go into making a quality supplement in today’s market. If you are interested in discovering more of these types of manufacturers, I suggest you check out our post The Best Supplement Brands: A Comprehensive Guide & Review, which compares the benefits of the leading supplement manufacturers on the market today.

Reviews of Supplement Brands

Now that you are well aware of the dangers that lurk in unknown supplements, and the benefits of buying pharmaceutical grade supplements, let’s review some of the best supplement manufacturers on the market. These supplement reviews provide a general overview of some of the best supplement brands on the market, which are used by health care professionals around the world. Most all of these products aren’t available in stores locally, but can be purchased directly through Amazon or Pureformulas.

Biotics Research
Biotics Research is an exceptionally trustworthy company, which produces supplements that set the bar for quality and purity. They produce all products in cGMP facilities, exceed FDA regulations, label EVERY ingredient, have a great quality assurance system, and offer very specialized synergistic formulations. Biotics Research is a 'Doctor-Trusted' Brand, and is only sold online and by licensed healthcare practitioners.Read full review
Available Online
Pure Encapsulations
Pure Encapsulations make supplements with ultra-pure ingredients. They produce everything in a certified GMP facility, are free from allergens, and typically only sell to licensed health practitioners. There prices are very reasonable for such high quality products, and very few have anything negative to say of them.Read full review
Available on Amazon
Douglas Laboratories
Douglas Laboratories represents what companies should drive to become—pure, socially-responsible, and innovators within their respective fields. They specialize in products addressing proper hormonal balance, have a well-established history as a Doctor Trusted Brand, produce products in cGMP facilities, and offer very difficult to find products at very competitive prices.Read full review
Available on Amazon
Vital Nutrients
Vital nutrients is regarded by many health professionals as offering a superior product. Vital Nutrients are considered to be leaders in the field of supplement quality assurance, offer a wide selection of difficult to find compounds, and are considered to be a Doctor Trusted Brand. Read full review
Available on Amazon
Designs for Health
Designs for Health produces some of the most sought-after niche-targeting supplements on the market. Be it their extensive line of products that are Paleo Diet friendly, or just other great synergistic supplements like GI Revive; Designs for Health is a Doctor Trusted Brand that is largely comprised of doctors itself. Slightly on the expensive side, but worth the money in most-cases.Read full review
Available on Amazon
Thorne Research
Thorne Research is comprised of health professionals that have dedicated themselves to creating a better awareness of the positive benefits associated with using supplements to address health concerns. They are rigidly monitored for quality assurance, have unique synergistic blends, and are considered a pharmaceutical grade Doctor Trusted Brand. Available in some stores, but readily found Online.Read full review
Available Directly from Thorne
Metagenics has a long track record of providing uniquely-formulated supplements which target very specific mechanisms in the body. As pioneers of the field of nutrigenomics—Metagenics holds hundreds of patents and produces valuable scientific research every year. While slightly more expensive than competitors, this Doctor Trusted Brand delivers a truly-unique product.Read full review
Available on Amazon
ProThera, along with their subsidy Klaire Labs, produce some of the world's most-potent commercially-sold probiotics. These products are excellent for digestive health, and provide a myriad of health benefits. These products are powerful, and a bit pricey compared to similar products available in stores. ProThera and Klaire Labs are both Doctor Trusted Brands used and prescribed by healthcare practitioners.Read full review
Available on Amazon


Pharmaceutical grade supplements offer themselves as powerful allies in the ability to help achieve, and maintain, a healthy balance. Health care professionals utilize these ultra-pure formulas to help ensure their patients aren’t being exposed to any unnecessary toxins, fillers, or otherwise unwanted ingredients. The truth is, you will benefit from choosing to purchase supplements from any of these manufacturers. You will find that each of them excel in different areas, while all excel in the area of product purity and bio-availability.

It is wise to regard all of these brands as a single option—pharmaceutical grade supplements—and choose from a combined product line to broaden your options. Helping to achieve, maintain, or restore a healthy balance to your body is quite possibly the most rewarding experience you’ll ever endeavor. The road can be challenging, filled with confusion, difficulty and frustration. Taking advantage of the purity and bioavailability that pharmaceutical grade supplements offer can help make this journey much more successful, as well as enjoyable.

Pharmaceutical Grade Supplements
Vital to Proper Diets
Pharmaceutical Grade Supplements are much more pure than most store-brand supplements, and even more pure than most brands found in health food stores. These ultra-pure supplements offer powerful results with much less risk of ingesting toxic chemicals or unwanted allergens. The brands that produce these supplements are trusted by doctors around the world to help treat their patients and help them reach their health goals.
Free of Allergens
No Unwanted Ingredients
No Pesticide Residue
Only 100% Pure Ingredients Used
Trusted by Doctors
More Expensive
Not Sold in Stores
Overall Rating
Available Online


Organicnewsroom is dedicated to sharing valuable health-related information to about diet, supplements, and healthy recipes.
Powerful Health Insights
Take Action Now!
Join over 10,000 like-minded subscribers in receiving powerful health tips, supplement guides, and insights into modern health issues you won't find anywhere else.
We don't share your information with anyone else.