Piracetam is a Nootropic compound discovered in the late 1970’s by a Romanian Psychologist investigating compounds capable of providing CNS relaxing effects. Piracetam is a member of the Racetam family all of which contain a single Pyrrolidone molecule. Piracetam is regarded as being one of the more mild Nootropics, and many anecdotal accounts suggest that not everyone may experience notable effects.

Piracetam Benefits

Clinical data on Piracetam suggests that this Nootropic compound may offer some tremendous benefit in those suffering from neurodegenerative conditions such as dementia, as well as those suffering from brain injury. Piracetam has been shown to be as effective as aspirin in the treatment of blood clotting, making it a candidate for usage in post-cardiac events. Additionally, researchers found that Piracetam was also tolerated much better over a long period of time compared to aspirin 1. Piracetam hasn’t had a wide range of clinical trials conducted on its potential benefit and application, despite its long age relative to many Nootropics.

Piracetam has been shown to be as effective as aspirin in the treatment of blood clotting

Piracetam’s most-notable benefit has been shown by researchers to be in the area of reducing the effects of dementia as well as the decrease in dementia-related neurological symptoms.  Piracetam has also demonstrated the ability to help boost short term memory as well as social engagement in many anecdotal accounts. One other odd benefit that has been seen by Piracetam in clinical trials is its ability to almost completely eliminate severe breath holding spells (BHS) in children 2. Many regard Piracetam as necessitating a ‘pre-loading’ period during usage, offering the fullest benefits after several weeks of use.

Piracetam Dosage

Piracetam is typically taken in doses ranging from 1mg to 4.5 mg in some clinical trials, and most anecdotal accounts describe ranges of 3.5 g as being an effective dose. As with other Racetams, and Nootropics in general, there isn’t nearly as wide a body of research to catalog the varying experiences with different doses.  Piracetam is a water soluble compound, and can easily be mixed with a glass of water and taken between meals, but will also offer benefits when taken with a meal. As with many Nootropic compounds, and specifically with those in the Racetam family, stacking use with a choline compound is recommended. Supplements such as Alpha GPC, CDP Choline, or Choline supplements are recommended to help handle the increased uptake of acetylcholine during use of compounds like Piracetam.

Piracetam vs Aniracetam

Compared to Aniracetam, Piracetam tends to offer a much more subtle effect and better suited for long-term use and neuroprotective applications. Piracetam has been shown to offer very stable results in lower and moderate doses up to 2 g, and may provide neuroprotective benefits over the course of it’s use. Aniracetam is regarded as being more stimulating, and is anecdotally reported as being better suited for short bursts of cognitive enhancement such as cramming for tests, solving complex problems, or improving environmental engagement such as in athletics. Aniracetam is a fat-soluble Nootropic, which is generally regarded as being more effective in crossing the blood brain barrier. The benefits of fat-soluble compounds are known to be seen much more quickly than comparable water-soluble compounds. For this reason, again, many regard Aniracetam as the best choice for short term usage, when quickly experiencing the effects is considered favorable.

Piracetam vs Oxiracetam

Compared to Oxiracetam, Piracetam is quite similar but regarded as generally offering much more subtle effects. Piracetam is often preferred by those looking for benefits to their overall outlook on life, and mood-enhancing actions. Oxiracetam has been known to be best-suited for use in more mentally-geared circumstances such as high-yield decision making, and strategy development. Piracetam has been noted by anecdotal evidence to increase sociability and offer more psychoactive benefits. Piracetam tends to be effective only at larger doses than Oxiracetam as well, with many users describing doses of 4 grams and higher.

Piracetam Side Effects

Piracetam is considered to be very safe for general use, although mild side effects can be noticed at higher doses. While doses of 4 grams and more are generally regarded as safe, Piracetam has LD50 of 5.6 mg/kg of body weight in rats, and 20 grams/kilogram of body weight in mice 3. LD50 is the dosage amount required to induce toxic death in 50% of a test population. In other words, if you give 10 mice, each weighing 1 kilogram, 20 grams of Piracetam, 5 of them will die. Considering that a 150 pound adult would have to take 1360 grams of Piracetam to near this level, it’s still considered to have acute toxicity. Piracetam has very few side effects, all of which are regarded as being generally mild and non-serious. A few of these include headaches, irritability, nervousness, and insomnia. Also of note, is that many users report a type of depressive withdrawal upon cessation of Piracetam.

Final Considerations

Piracetam is one of the original compounds known as Nootropics, discovered in the late 1970’s. It’s renowned for providing mild mental effects, and is generally regarded as safe for use. Piracetam isn’t approved by the FDA as a dietary ingredient, and is therefore sometimes difficult to find for purchase. We recommend the Piracetam product from Nootropics.com for anyone looking to source a quality source for their own experimentation. Nootropics offer a powerful ability to help modulate and upregulate certain natural cognitive processes. This manipulation can lend quite beneficial and positive experiences in many cases, though little clinical data exists to account for potential long term side effects. Anytime you purposefully insert a compound meant to alter natural cognitive processes rather than support them—you run a very real risk of catalyzing unforeseen consequences.

Piracetam is the original Nootropic, having been discovered in the late 1970's. It is reported to offer mild cognitive enhancing effects, and has some research describing it as potentially offering several health benefits.
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